Any of a group of inherited disorders of hemoglobin metabolism in which there is a decrease in net synthesis of a particular globin chain without change in the structure of that chain;several genetic types exists;and the corresponding clinical picture may vary from barely detectable hematologic abnormality to severe and fatal anaemia.The hemoglobin lepore syndromes are clinically indistinguishable,but the non-alpha-globin chains are structurally altered

Symptoms/Problems Remedy frequency(doses)
To increase the time period of successive blood-transfusion;aplastic anaemia T.N.T.200 weekly(12)